ABSTRACT
Abstract This meta-analysis aimed to investigate the effects of propolis on the severity of coronavirus disease symptoms by reducing periodontal disease. PubMed, EMBASE, SciELO, Web of Science, and SCOPUS databases were systematically searched. Studies have been conducted analyzing propolis's effects on COVID-19 and periodontitis. The study was conducted according to the PRISMA statement and registered in PROSPERO. Risk of Bias (RoB) assessment and meta-analysis of clinical studies were performed (Review Manager 5, Cochrane). The certainty of the evidence was assessed using GradePro (GDT). Studies have shown propolis flavonoids inhibit viral replication in several DNA and RNA viruses, including coronaviruses. Propolis components have an aminopeptidase inhibitor activity that can inhibit the main proteases of SARS viruses and seem to inhibit protein spikes, which are sites of most mutations in SARS-CoV strains. The meta-analysis showed favorable results with the use of propolis on probing depth (95%CI: 0.92; p < 0.001), clinical attachment level (95%CI: 1.48; p < 0.001), gingival index (95%CI: 0.14; p = 0.03), plaque index (95%CI: 0.11; p = 0.23), and blending on probing (95%CI: 0.39; p < 0.001). The antibacterial activity of propolis could be mediated through its direct action on microorganisms or the stimulation of the immune system, activating natural defenses. Thus, propolis inhibits the replication of SARS-CoV-2 as well as its bacterial activity. Treatment with propolis improves general health and facilitates the activation of the immune system against coronavirus.
ABSTRACT
ABSTRACT Introduction: Several oral problems may be perceived in individuals who were submitted to bariatric surgery, due to metabolic and behavioral changes relative to diet and oral hygiene. Tooth wear appears to suffer impact after bariatric surgery, because there may be an increase in gastroesophageal reflux. Objective: To systematically review the literature regarding the impact of bariatric surgery on gastroesophageal reflux and tooth wear. Method: The following databases were accessed by two independent, calibrated examiners: PubMed, Medline, Lilacs, Scielo and Cochrane using the following descriptors: "bariatric surgery" AND "dental erosion" OR "bariatric surgery" AND "dental erosion" AND "gastroesophageal reflux disease". After excluding duplicate studies, 12 studies were initially evaluated by the title and abstract. The excluded studies were those without relevance to the present research, literature review studies and case reports. Thus, four articles were included in this study. All the articles evaluated indicated high association between gastroesophageal reflux and tooth wear in patients submitted to bariatric surgery. Association of these outcomes was more evident six months after the surgical procedure. Conclusion: Patients submitted to bariatric surgery showed higher prevalence of gastroesophageal reflux and tooth wear.
RESUMO Introdução: Diversos problemas bucais podem ser percebidos nos indivíduos que foram submetidos à cirurgia bariátrica, frente às mudanças metabólicas e comportamentais referentes à alimentação e higienização. O desgaste dentário parece sofrer impacto após a cirurgia bariátrica, uma vez que pode ocorrer o aumento do refluxo gastresofágico após a operação. Objetivo: Analisar o impacto da cirurgia bariátrica no refluxo gastresofágico e no desgaste dentário por meio de uma revisão sistemática da literatura. Método: As seguintes bases de dados foram acessadas por dois examinadores independentes e calibrados: PubMed, Medline, Lilacs, Scielo e Cochrane usando os descritores: "bariatric surgery" AND "dental erosion" OR "bariatric surgery" AND "dental erosion" AND "gastroesophageal reflux disease". Após a exclusão dos estudos duplicados, 12 estudos foram avaliados inicialmente pelo título e resumo. Foram excluídos os sem relevância para a presente pesquisa, os de revisão da literatura e os relatos de caso. Sendo assim, foram incluídos neste estudo quatro artigos. Todos os artigos avaliados indicaram uma alta associação entre refluxo gastresofágico e desgaste dentário em pacientes submetidos à cirurgia bariátrica. A associação destes desfechos foi mais evidente após seis meses do procedimento cirúrgico. Conclusão: Pacientes submetidos à cirurgia bariátrica mostram maior prevalência de refluxo gastresofágico e desgaste dentário.